Herein, a new reductive-responsive pillar[5]arene-based, single-molecule-layer polymer nanocapsule is constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in a reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer drug shows excellent inhibition for tumor cell proliferation and exhibits low side effect on normal cells. This work not only demonstrates the development of a new reductive-responsive single molecular layer polymer nanocapsule for anticancer drug targeting delivery but also extends the design of smart materials for biomedical applications.

中文翻译：

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侧向功能化支柱[5]芳烃制备的还原反应，单分子聚合物纳米胶囊靶向抗癌药物的传递。

本文中，构建了一种新的基于还原反应的基于支柱[5]芳烃的单分子层聚合物纳米胶囊，用于药物递送。该功能化的系统显示出良好的生物相容性，有效内化到靶细胞中以及在还原性环境（例如细胞质）中明显触发包埋药物的释放。此外，这种装有抗癌药的智能载体对肿瘤细胞的增殖表现出优异的抑制作用，并且对正常细胞的副作用低。这项工作不仅证明了用于抗癌药物靶向递送的新型还原反应性单分子层聚合物纳米胶囊的开发，而且还扩展了生物医学应用的智能材料的设计。