A new protocol of photoredox‐mediated Minisci alkylation of N‐heteroarenes with aliphatic carboxylic acids has been developed. Using Ru(bpy)₃Cl₂ as photocatalyst and acetoxybenziodoxole (BI–OAc) as oxidant, a variety of primary, secondary and tertiary alkyl groups can be efficiently incorporated into various electron‐deficient N‐heteroarenes. This protocol demonstrated excellent substrate scope and good functional group tolerance and can be applied to late‐stage functionalization of complex molecules.

中文翻译：

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使用羧酸和高价碘的光氧化还原介导的N-杂芳烃的Minisci烷基化

已经开发出了一种新的光催化由N-杂芳烃进行的氧化还原介导的Minisci烷基化的方法，该方法采用脂肪族羧酸。使用Ru（bpy）₃ Cl ₂作为光催化剂和乙酰氧基苯并恶唑（BI-OAc）作为氧化剂，可以将各种伯，仲和叔烷基有效地掺入各种缺电子的N-杂芳烃中。该方案证明了优异的底物范围和良好的官能团耐受性，可用于复杂分子的后期功能化。