We describe a scalable device design of a dense array of multiple nanopores made from nanoscale semiconductor materials to detect and identify translocations of many biomolecules in a massively parallel detection scheme. We use molecular dynamics coupled to nanoscale device simulations to illustrate the ability of this device setup to uniquely identify DNA parallel translocations. We show that the transverse sheet currents along membranes are immune to the crosstalk effects arising from simultaneous translocations of biomolecules through multiple pores, due to their ability to sense only the local potential changes. We also show that electronic sensing across the nanopore membrane offers a higher detection resolution compared to ionic current blocking technique in a multipore setup, irrespective of the irregularities that occur while fabricating the nanopores in a two-dimensional membrane.

中文翻译：

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二维固态多孔系统大规模并行DNA检测

我们描述了由纳米级半导体材料制成的多个纳米孔的密集阵列的可扩展设备设计，以大规模并行检测方案检测和识别许多生物分子的易位。我们使用耦合到纳米级设备模拟的分子动力学来说明这种设备设置独特地识别DNA平行易位的能力。我们表明，沿膜的横向薄层电流不受生物分子同时通过多个孔易位所引起的串扰影响，这是由于它们仅能感知局部电势变化的能力。我们还显示，与多孔设置中的离子电流阻断技术相比，跨纳米孔膜的电子传感提供了更高的检测分辨率，