A Magnetically Responsive Biomaterial System for Flexibly Regulating the Duration between Pro- and Anti-Inflammatory Cytokine Deliveries.,Advanced Healthcare Materials

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A Magnetically Responsive Biomaterial System for Flexibly Regulating the Duration between Pro- and Anti-Inflammatory Cytokine Deliveries.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-04-16 , DOI: 10.1002/adhm.201800227
Anita E Tolouei ₁ , Nihan Dülger ₁ , Rosa Ghatee ₁ , Stephen Kennedy _{1,

2}

Affiliation

While inflammation can be problematic, it is nonetheless necessary for proper tissue regeneration. However, it remains unclear how the magnitude and duration of the inflammatory response impacts regenerative outcome. This is partially due to the difficulty in temporally regulating macrophage phenotype at wound sites. Here, a magnetically responsive biomaterial system potentially capable of temporally regulating macrophage phenotypes through sequential, on‐demand cytokine deliveries is presented. This material system is designed to (i) rapidly recruit proinflammatory macrophages (M1) through initial cytokine deliveries and (ii) subsequently transition macrophages toward anti‐inflammatory phenotypes (M2s) through delayed, magnetically triggered cytokine release. Here, the ability of this system to initially deliver proinflammatory cytokines (i.e., monocyte chemoattractant protein‐1 and interferon gamma), recruit, and harbor an expanding macrophage population, and delay deliveries of anti‐inflammatory cytokines (i.e., IL‐4 and IL‐10) until the application of magnetic fields from simple hand‐held magnets is demonstrated. Critically, the timing and rate of these delayed deliveries can be remotely/magnetically controlled. This biomaterial system can provide a powerful tool in (i) understanding the relationship between inflammation and regenerative outcome, (ii) developing optimized cytokine delivery strategies, and (iii) clinically implementing those optimized delivery strategies with the on‐demand versatility needed to alter the course of therapies in real time.

中文翻译：

一种磁响应生物材料系统，用于灵活调节促炎细胞因子和抗炎细胞因子输送之间的持续时间。

虽然炎症可能会带来问题，但它对于适当的组织再生仍然是必要的。然而，目前尚不清楚炎症反应的程度和持续时间如何影响再生结果。这部分是由于难以暂时调节伤口部位的巨噬细胞表型。在这里，提出了一种磁响应生物材料系统，可能能够通过顺序、按需的细胞因子递送来暂时调节巨噬细胞表型。该材料系统的设计目的是（i）通过初始细胞因子递送快速招募促炎巨噬细胞（M1），以及（ii）随后通过延迟、磁性触发的细胞因子释放将巨噬细胞转变为抗炎表型（M2）。在此，该系统能够最初递送促炎细胞因子（即单核细胞趋化蛋白-1和干扰素γ）、招募和容纳不断扩大的巨噬细胞群，并延迟递送抗炎细胞因子（即IL-4和IL） ‐10）直到演示了简单手持磁铁的磁场应用。至关重要的是，这些延迟交付的时间和速率可以远程/磁性控制。该生物材料系统可以提供一个强大的工具，以（i）了解炎症和再生结果之间的关系，（ii）开发优化的细胞因子递送策略，以及（iii）临床实施这些优化的递送策略，并根据需要改变细胞因子所需的多功能性。实时治疗过程。

更新日期：2018-04-16

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