Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-04-12 , DOI: 10.1016/j.tetlet.2018.04.029 Prasanjit Ghosh , Aritra Kumar Nandi , Sajal Das
Carbonylative Sonogashira annulation sequence for one pot synthesis of 4-quinolone and 4H-chromen-4-one has been developed in presence of Pd-NHC catalyst. Substituted 2-iodoaniline and 2-iodophenol independently underwent in the carbonylative Sonogashira annulation reaction with a variety of acetylenes to result in 4-quinolone and flavone derivatives respectively in good to excellent yield. Moreover, this protocol does not require toxic CO gas, high catalyst loading and any expensive salt/additive. Herein we, for the first time, are using Mo(CO)6, as solid CO source for the one pot synthesis of flavone derivatives via carbonylative Sonogashira annulation reaction.
中文翻译:
羰基化Sonogashira环空序列:一锅合成4-quinolone和4 H -chromen-4-one衍生物
在Pd-NHC催化剂的存在下,已经开发了用于一锅合成4-喹诺酮和4 H -chromen-4-one的羰基化Sonogashira环化序列。在羰基化的Sonogashira与多种乙炔的环化反应中,分别进行取代的2-碘苯胺和2-碘苯酚的合成,分别以良好或优异的收率得到4-喹诺酮和黄酮衍生物。而且,该方案不需要有毒的CO气体,高催化剂负载量和任何昂贵的盐/添加剂。本文中,我们首次使用Mo(CO)6作为固体CO源,用于通过羰基化Sonogashira环化反应一锅合成黄酮衍生物。