Hierarchical Self‐Assembly Induced by Dilution‐Enhanced Hydrophobic Hydration,Chemistry - A European Journal

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Hierarchical Self‐Assembly Induced by Dilution‐Enhanced Hydrophobic Hydration
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-04-16 , DOI: 10.1002/chem.201801213
Dapeng Liu ₁ , Xiaosong Wang ₁

Affiliation

Hydrophobic hydration (HH) is crucial in protein chemistry. Its role in the organization of molecules in water, however, remains elusive and difficult to investigate without appropriate model systems. Metal carbonyl vesicles (MCsomes), assembled from hydrophobic Fp(CH₂)₆Azobenzene^trans (Fp head=(PPh₃)(Cp)Fe(CO)(CO‐); hydrocarbon tail=(CH₂)₆Azobenzene^trans; trans:trans configuration) is dispersible in water via HH of the Fp heads. We examined the dependence of this HH on solution conditions by taking advantage of redox activity and fluorescence quenching ability of hydrated Fe elements. A subtle variation in the HH substantially varied the solution behaviour of the MCsomes for hierarchical structural evolutions. This scrutiny resolved a long‐standing challenge to explicate the role of HH in self‐assembly at molecular levels, an imperative step to understand the biological systems.

中文翻译：

稀释增强的疏水水合引起的分层自组装

疏水水合（HH）在蛋白质化学中至关重要。但是，它在水中分子组织中的作用仍然难以捉摸，并且如果没有合适的模型系统就很难进行研究。金属羰基囊泡（MCsomes），由疏水性FP（CH组装₂）_6克偶氮苯^的反式（Fp的头=（PPH ₃）（CP）的Fe（CO）（CO - ）;烃尾部=（CH ₂）_6克偶氮苯^的反式;反：反式构型）可通过Fp头的HH分散在水中。我们通过利用氧化铁活性和水合铁元素的荧光猝灭能力，研究了这种HH对溶液条件的依赖性。HH的细微变化极大地改变了MCsomes对于分层结构演化的溶解行为。这项审查解决了一个长期的挑战，即在分子水平上阐明HH在自组装中的作用，这是了解生物学系统的必不可少的步骤。

更新日期：2018-04-16

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