Capturing platinum in cisplatin: kinetic reactions with recombinant human apo-metallothionein 1a†,Metallomics

当前位置： X-MOL 学术 › Metallomics › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Capturing platinum in cisplatin: kinetic reactions with recombinant human apo-metallothionein 1a†
Metallomics ( IF 2.9 ) Pub Date : 2018-04-17 00:00:00 , DOI: 10.1039/c8mt00029h
Daisy L. Wong _{1,

2,

3,

4,

5} , Martin J. Stillman _{1,

2,

3,

4,

5}

Affiliation

cis-Diamminedichloroplatinum(II) (cisplatin), a powerful chemotherapeutic, can incur chemoresistance in cancers, reducing therapeutic success. Metallothioneins (MTs) are suspected of metallodrug interference via ligand removal and metal sequestration. The mechanistic details and reactions rates k_obs for the systematic deconstruction of cisplatin by apo-human MT are reported and analysed from mass spectral data.

中文翻译：

捕获铂在顺铂：用重组人脱辅基金属硫蛋白1A动力学反应†

顺式-Diamminedichloroplatinum（II）（顺铂）是一种强大的化学治疗剂，可引起癌症的化学耐药性，降低治疗成功率。金属硫蛋白（MTs）被怀疑通过配体去除和金属螯合而干扰了金属药物。载脂蛋白人类MT系统解构顺铂的机理细节和反应速率k _obs已有报道并从质谱数据中进行了分析。

更新日期：2018-04-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11