The physicochemical properties of silver nanoparticles (AgNPs) in human whole saliva are investigated herein. In authentic saliva samples, AgNPs exhibit a great stability with over 70% of the nanomaterial remaining intact after a 24-h incubation in the presence of ∼0.3 mM dissolved oxygen. The small loss of AgNPs from the saliva sample has been demonstrated to be a result of two processes: agglomeration/aggregation (not involving oxygen) and oxidative dissolution of AgNPs (assisted by oxygen). In authentic saliva, AgNPs are also shown to be more inert both chemically (silver oxidative dissolution) and electrochemically (electron transfer at an electrode) than in synthetic saliva or aqueous electrolytes. The results thus predict based on the chemical persistence (over a 24-h study) of AgNPs in saliva and hence the minimal release of hazardous Ag⁺ and reactive oxygen species that the AgNPs are less likely to cause serious harm to the oral cavity but this persistence may enable their transport to other environments.

中文翻译：

---

银纳米颗粒在真实人类唾液中的命运

本文研究了人类整个唾液中银纳米颗粒（AgNPs）的理化特性。在真实的唾液样品中，AgNP表现出很大的稳定性，在约0.3 mM溶解氧存在下进行24小时孵育后，超过70％的纳米材料保持完整。已证明唾液样品中AgNP的少量损失是两个过程的结果：结块/聚集（不涉及氧气）和AgNP的氧化溶解（由氧气辅助）。在真实的唾液中，与合成唾液或水性电解质相比，AgNPs在化学（银氧化溶解）和电化学（电极上的电子转移）方面也表现出更高的惰性。因此，结果是基于唾液中AgNP的化学持久性（经过24小时研究）预测的，因此可以预测有害Ag的最小释放量⁺和活性氧的的AgNPs不太可能造成严重损害口腔，但这持久性可以使他们的运输到其他环境。