PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells,Environmental Science & Technology Letters

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PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2018-04-16 , DOI: 10.1021/acs.estlett.8b00193
Shuyu Liu _{1,

2} , Nuoya Yin _{1,

2} , Francesco Faiola _{1,

2}

Affiliation

The two most infamous perfluoroalkyl acids, PFOA and PFOS, are persistent, widespread, bioaccumulative, and associated with many health issues. However, knowledge about their potential toxicity to the developing pancreas or their association with metabolic diseases, such as diabetes, in humans is limited. In this study, we investigated the effects of PFOA and PFOS on the in vitro generation of pancreatic progenitor cells from human embryonic stem cells, a process that mimics in vivo organogenesis. We demonstrated for the first time that these two pollutants significantly affect the early stages of human pancreatic progenitor cell specification, even at very low environmentally and human-relevant doses. Thus, our findings further emphasize the substantial health risks associated with prenatal exposure to PFOA and PFOS.

中文翻译：

PFOA和PFOS破坏人类胰腺祖细胞的生成

两种臭名昭著的全氟烷基酸PFOA和PFOS具有持久性，广泛性，生物蓄积性，并与许多健康问题相关。然而，关于它们对人类发展中的胰腺的潜在毒性或它们与诸如糖尿病的代谢性疾病的关联的知识是有限的。在这项研究中，我们研究了全氟辛酸和全氟辛烷磺酸对人胚胎干细胞体外生成胰腺祖细胞的作用，该过程模仿体内器官发生。我们首次证明，即使在非常低的环境和与人类有关的剂量下，这两种污染物也会显着影响人类胰腺祖细胞规格的早期阶段。因此，我们的发现进一步强调了与产前暴露于PFOA和PFOS相关的重大健康风险。

更新日期：2018-04-17

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