A ratiometric iron probe enables investigation of iron distribution within tumour spheroids†,Metallomics

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A ratiometric iron probe enables investigation of iron distribution within tumour spheroids†
Metallomics ( IF 2.9 ) Pub Date : 2018-04-16 00:00:00 , DOI: 10.1039/c7mt00297a
Isaac J. Carney _{1,

2,

3} , Jacek L. Kolanowski _{1,

2,

3} , Zelong Lim _{1,

2,

3} , Benjamin Chekroun _{1,

2,

3} , Angela G. Torrisi _{1,

2,

3} , Trevor W. Hambley _{1,

2,

3} , Elizabeth J. New _{1,

2,

3}

Affiliation

Iron dysregulation is implicated in numerous diseases, and iron homeostasis is profoundly influenced by the labile iron pool (LIP). Tools to easily observe changes in the LIP are limited, with calcein AM-based assays most widely used. We describe here FlCFe1, a ratiometric analogue of calcein AM, which also provides the capacity for imaging iron in 3D cell models.

中文翻译：

比例铁探针可以研究肿瘤球体中铁的分布情况†

铁失调与多种疾病有关，并且不稳定的铁池（LIP）对铁的体内平衡产生深远的影响。可以轻松观察LIP变化的工具有限，其中最广泛使用的是基于钙黄绿素AM的检测方法。我们在这里描述FlCFe1，钙黄绿素AM的比率类似物，它还提供了在3D细胞模型中对铁成像的能力。

更新日期：2018-04-16

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