A telomerase‐responsive DNA icosahedron was designed to precisely release caged platinum nanodrugs into cisplatin‐resistance tumor cells for effective therapy. This DNA icosahedron was constructed from two pyramidal DNA cages connected with telomerase primers and telomeric repeats, and platinum nanodrugs were then encapsulated into the DNA structure. In the presence of telomerase, the primers are extended, leading to inner‐chain substitution of the DNA icosahedron and subsequent release of the caged nanodrugs. This DNA icosahedron can precisely release caged nanodrugs in response to telomerase in tumor cells, giving enhanced anticancer efficacy in drug‐resistant carcinoma and with reduced toxicity to normal tissues. We speculate that this precisely designed, well controlled DNA cage could be generalized to diverse anticancer drugs.

中文翻译：

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端粒酶反应性DNA二十面体将铂纳米药物精确递送至抗顺铂癌症。

设计了端粒酶反应性DNA二十面体，以将笼中的铂纳米药物精确释放到顺铂耐药性肿瘤细胞中，以进行有效治疗。此DNA二十面体由两个与端粒酶引物和端粒重复序列相连的金字塔形DNA笼构建而成，然后将铂纳米药物封装到DNA结构中。存在端粒酶时，引物会延伸，导致DNA二十面体的内链取代，并随后释放笼中的纳米药物。这种DNA二十面体可以响应肿瘤细胞中的端粒酶精确释放笼状纳米药物，从而增强了对耐药癌的抗癌功效，并降低了对正常组织的毒性。我们推测，这种精确设计，控制良好的DNA笼子可以推广到各种抗癌药物。