A facile two-step synthesis of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate (Still–Gennari reagent) has been developed by exploiting Garegg–Samuelsson reaction conditions. Starting from trimethyl phosphonoacetate, Still–Gennari reagent was prepared in 94% yield via methyl 2-{bis[(trimethylsilyl)oxy]phosphoryl}acetate intermediate. This synthetic procedure was also used to prepare some kinds of Horner–Wadsworth–Emmons reagents and related compounds.

中文翻译：

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利用 Garegg-Samuelsson 反应条件轻松两步合成双(2,2,2-三氟乙基)膦酰基乙酸甲酯

利用 Garegg-Samuelsson 反应条件开发了一种简便的双（2,2,2-三氟乙基）膦酰基乙酸甲酯（Still-Gennari 试剂）的两步合成方法。从膦酰基乙酸三甲酯开始，通过 2-{双[（三甲基甲硅烷基）氧基]磷酰基}乙酸甲酯中间体，以 94% 的产率制备了 Still-Gennari 试剂。该合成程序还用于制备某些类型的 Horner-Wadsworth-Emmons 试剂和相关化合物。