当前位置：
X-MOL 学术
›
ACS Appl. Mater. Interfaces
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
pH-Responsive Magnetic Mesoporous Silica-Based Nanoplatform for Synergistic Photodynamic Therapy/Chemotherapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-12 00:00:00 , DOI: 10.1021/acsami.7b19797 Xiang-long Tang 1 , Feng Jing 1 , Ben-lan Lin 1 , Sheng Cui 1 , Ru-tong Yu 2 , Xiao-dong Shen 1 , Ting-wei Wang 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-12 00:00:00 , DOI: 10.1021/acsami.7b19797 Xiang-long Tang 1 , Feng Jing 1 , Ben-lan Lin 1 , Sheng Cui 1 , Ru-tong Yu 2 , Xiao-dong Shen 1 , Ting-wei Wang 1
Affiliation
|
By overcoming drug resistance and subsequently enhancing the treatment, the combination therapy of photodynamic therapy (PDT) and chemotherapy has promising potential for cancer treatment. However, the major challenge is how to establish an advanced nanoplatform that can be efficiently guided to tumor sites and can then stably release both chemotherapy drugs and a photosensitizer simultaneously and precisely. In this study, which considered the possibility and targeting efficiency of a magnetic targeting strategy, a novel Fe3O4@mSiO2(DOX)@HSA(Ce6) nanoplatform was successfully built; this platform could be employed as an efficient synergistic antitumor nanoplatform with magnetic guidance for highly specific targeting and retention. Doxorubicin (DOX) molecules were loaded into mesoporous silica with high loading capability, and the mesoporous channels were blocked by a polydopamine coating. Human serum albumin (HSA) was conjugated to the outer surface to increase the biocompatibility and blood circulation time, as well as to provide a vehicle for loading photosensitizer chlorin e6 (Ce6). The sustained release of DOX under acidic conditions and the PDT induced by red light exerted a synergistic inhibitory effect on glioma cells. Our experiments demonstrated that the pH-responsive Fe3O4@mSiO2(DOX)@HSA(Ce6) nanoplatform was guided to the tumor region by magnetic targeting and that the nanoplatform suppressed glioma tumor growth efficiently, implying that the system is a highly promising photodynamic therapy/chemotherapy combination nanoplatform with synergistic effects for cancer treatment.
中文翻译：
基于pH响应的磁介孔二氧化硅纳米平台，用于协同光动力疗法/化学疗法。
通过克服耐药性并随后加强治疗，光动力疗法（PDT）和化学疗法的联合疗法在癌症治疗方面具有广阔的前景。然而，主要的挑战是如何建立一种先进的纳米平台，该平台可以有效地引导至肿瘤部位，然后可以稳定而稳定地同时释放化疗药物和光敏剂。在这项研究中，考虑了磁性靶向策略的可能性和靶向效率，一种新型的Fe 3 O 4 @mSiO 2成功构建（DOX）@HSA（Ce6）纳米平台；该平台可用作具有磁性导向的高效协同抗肿瘤纳米平台，可实现高度特异性的靶向和保留。将阿霉素（DOX）分子负载到具有高负载能力的介孔二氧化硅中，并且介孔通道被聚多巴胺涂层阻塞。将人血清白蛋白（HSA）与外表面结合，以增加生物相容性和血液循环时间，并提供载有光敏剂二氢卟酚e6（Ce6）的载体。酸性条件下DOX的持续释放和红光诱导的PDT对神经胶质瘤细胞产生协同抑制作用。我们的实验表明，pH响应的Fe 3 O 4 @mSiO 2（DOX）@HSA（Ce6）纳米平台通过磁性靶向被引导至肿瘤区域，并且该纳米平台有效地抑制了神经胶质瘤的肿瘤生长，这表明该系统是一种高度有前途的光动力疗法/化学疗法结合的纳米平台，具有协同治疗癌症的作用。
更新日期：2018-04-12
中文翻译：
基于pH响应的磁介孔二氧化硅纳米平台，用于协同光动力疗法/化学疗法。
通过克服耐药性并随后加强治疗，光动力疗法（PDT）和化学疗法的联合疗法在癌症治疗方面具有广阔的前景。然而，主要的挑战是如何建立一种先进的纳米平台，该平台可以有效地引导至肿瘤部位，然后可以稳定而稳定地同时释放化疗药物和光敏剂。在这项研究中，考虑了磁性靶向策略的可能性和靶向效率，一种新型的Fe 3 O 4 @mSiO 2成功构建（DOX）@HSA（Ce6）纳米平台；该平台可用作具有磁性导向的高效协同抗肿瘤纳米平台，可实现高度特异性的靶向和保留。将阿霉素（DOX）分子负载到具有高负载能力的介孔二氧化硅中，并且介孔通道被聚多巴胺涂层阻塞。将人血清白蛋白（HSA）与外表面结合，以增加生物相容性和血液循环时间，并提供载有光敏剂二氢卟酚e6（Ce6）的载体。酸性条件下DOX的持续释放和红光诱导的PDT对神经胶质瘤细胞产生协同抑制作用。我们的实验表明，pH响应的Fe 3 O 4 @mSiO 2（DOX）@HSA（Ce6）纳米平台通过磁性靶向被引导至肿瘤区域，并且该纳米平台有效地抑制了神经胶质瘤的肿瘤生长，这表明该系统是一种高度有前途的光动力疗法/化学疗法结合的纳米平台，具有协同治疗癌症的作用。
京公网安备 11010802027423号