Gold‐Catalyzed Oxidative Cyclization of Tryptamine Derived Enynamides: A Stereoselective Approach to Tetracyclic Spiroindolines,Advanced Synthesis & Catalysis

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Gold‐Catalyzed Oxidative Cyclization of Tryptamine Derived Enynamides: A Stereoselective Approach to Tetracyclic Spiroindolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-04-20 , DOI: 10.1002/adsc.201800001
Meijun Lin _{1,

2} , Lei Zhu _{1,

3} , Jiajin Xia _{1,

3} , Yinghua Yu ₁ , Jianxin Chen ₂ , Zhifeng Mao ₁ , Xueliang Huang _{1,

3}

Affiliation

In this work, we describe a new gold‐catalyzed oxidative cascade cyclization of conjugated enynamides. The reaction could be carried out under relatively mild condition. In presence of a cationic gold catalyst bearing an N‐heterocyclic carbene ligand, enynamides derived from tryptamine react with pyridine N‐oxide, leading to the formation of a variety of tetracyclic spiroindolines in a stereoselective manner.

中文翻译：

色胺衍生的乙酰胺的金催化的氧化环化：四环螺吲哚啉的立体选择性方法。

在这项工作中，我们描述了一种新的金催化的共轭乙酰胺的氧化级联环化反应。该反应可以在相对温和的条件下进行。在带有N杂环卡宾配体的阳离子金催化剂的存在下，由色胺产生的烯酰胺与吡啶N氧化物反应，导致以立体选择性的方式形成各种四环螺二氢吲哚。

更新日期：2018-04-20

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