Two new glycosylated piericidins, glucopiericidinol A₃ (1) and 7-demethyl-glucopiericidin A (2), along with four known analogs were isolated from the culture broth of Streptomyces sp. KIB-H1083. The chemical structures of new compounds were elucidated by spectroscopic analyses. Their cytotoxicity on HL-60, SMMC-772, A-549, MCF-7, and SW480 cell lines, as well as antimicrobial activities was evaluated. The results showed that glucopiericidin A (4) has potent cytotoxicity against HL-60, SMMC-772, A-549, and MCF-7 cell lines with IC₅₀ values of 0.34, 0.65, 0.60, and 0.50 μM, respectively. For the antimicrobial activity, piericidin A (6) showed most powerful inhibitory activities against Xanthomonas oryzae pv. oryzicola, and Penicillium decumbens.

中文翻译：

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来自内生链霉菌的糖基化的杀菌素，具有细胞毒性和抗菌活性。

从链霉菌属（Streptomyces sp。）的培养液中分离出两个新的糖基化的匹维菌素，糖基哌啶醇A ₃（1）和7-去甲基-糖基哌啶醇A（2），以及四个已知的类似物。KIB-H1083。通过光谱分析阐明了新化合物的化学结构。评估了它们对HL-60，SMMC-772，A-549，MCF-7和SW480细胞系的细胞毒性以及抗菌活性。结果表明，糖抗胆红素A（4）对HL-60，SMMC-772，A-549和MCF-7细胞系具有有效的细胞毒性，IC ₅₀值分别为0.34、0.65、0.60和0.50μM 。对于抗菌活性，piericidin A（6）对米生黄单胞菌（Panthomonas oryzae pv）表现出最强的抑制活性。Oryzicola和青霉。