Photo-induced anticancer activity and singlet oxygen production of prodigiosenes†,Photochemical & Photobiological Sciences

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Photo-induced anticancer activity and singlet oxygen production of prodigiosenes†
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-04-12 00:00:00 , DOI: 10.1039/c8pp00060c
Huguette Savoie _{1,

2,

3,

4} , Carlotta Figliola _{1,

5,

6,

7} , Estelle Marchal _{1,

5,

6,

7} , Bry W. Crabbe _{1,

7,

8,

9} , Geniece L. Hallett-Tapley _{1,

7,

8,

9} , Ross W. Boyle _{1,

2,

3,

4} , Alison Thompson _{1,

5,

6,

7}

Affiliation

The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER− and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.

中文翻译：

dig的光诱导抗癌活性和单线态氧的产生†

据报道，光生前黄酮的细胞毒性。一种黄dig烯代表天然产物原黄dig素的合成类似物，而两种则缀合到靶向雌激素受体（ER）的分子上。报道了对三种dig的孵化和辐照框架的比较，并探索了针对ER-和ER +细胞系的活性。此外，证明了三种pro的光敏性产生单线态氧的能力，将机制光释放到这类三吡咯的可能的光动力治疗作用上。

更新日期：2018-04-12

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