A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with β-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol.

中文翻译：

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对映选择性 Ni-Al 双金属催化咪唑与烯烃的外选择性 C-H 环化

已开发出 Ni-Al 双金属催化的咪唑与烯烃的对映选择性 CH 外选择性环化。以高达 98% 的产率和 >99% 的 ee 获得了一系列具有 β-立体中心的双环或多环咪唑。事实证明，双功能 SPO 配体促进的双金属催化对于这种具有挑战性的立体控制至关重要。