Phytochemical investigation of the methanolic extract of Lepidium sativum seeds led to the isolation of a new compound, named 2-(3-(3-((1H-imidazol-2-yl)methyl)-5-methoxy phenoxy)benzyl)-1H-imidazole and given the trivial name Lepidine AK (1), along with three known compounds; Lepidine E (2), Lepidine B (3) and 2-(3-(2-((1H-imidazol-2-yl)methyl)-6-methoxphenoxy)benzyl)-1H-imidazole (4). The structures were elucidated based on NMR spectroscopy, UV, IR and high-resolution electrospray ionization mass spectrometry. The isolated compounds were tested for bacterial conjugation inhibition. Lepidine AK (1, 100 μg/mL) reduced the conjugal transfer of the IncI₂ plasmid TP114 to 44.7±3.5% but interestingly promoted the conjugation of the IncN plasmid pKM101 to greater than 120%.

茄子种子甲醇提取物的植物化学研究导致分离出一种新化合物，名为2-（3-（3-（（（1 H-咪唑-2-基）甲基）-5-甲氧基苯氧基）苄基）- 1 H-咪唑，并被赋予小名字Leptidine AK（1），以及三种已知化合物；Lepidine E（2），Lepidine B（3）和2-（3-（2-（（1 H-咪唑-2-基）甲基）-6-甲氧苯氧基）苄基）-1 H-咪唑（4）。基于NMR光谱，UV，IR和高分辨率电喷雾电离质谱法阐明了结构。测试分离的化合物的细菌结合抑制作用。Lepidine AK（在图1中，100μg/ mL）将IncI ₂质粒TP114的结合转移降低至44.7±3.5％，但是有趣地将IncN质粒pKM101的结合转移至大于120％。