Background

Phenolic compounds¹ are one of the main interested nutraceuticals in the food and pharmaceutical industries. The application of phenolics is limited due to their low bioavailability, low solubility, low stability, and un-targeted release. These limitations could be overcome by novel ‘‘lipid-based nano-encapsulation technologies’’ capable of appropriated and targeted delivery functions into foods.

Scope and approach

In this review, preparation, application, and characterization of lipid-based nanocarriers for phenolics have been considered and discussed including nano-emulsions, nano-scale phospholipids, and nanostructured lipid carriers. The bioavailability of nano-encapsulated phenolic products and capability of them to produce functional foods have been considered as well.

Key findings and conclusions

In the food and nutraceutical industries, the main aims of loading phenolics into nanocarriers are masking their undesirable flavor for oral administration, providing high stability and high absorption, and better release in gastrointestinal (GIT) conditions. Compared with micro-sized carriers, nanocapsules based on lipid formulations provide more surface area and have the potential to enhance solubility, improve bioavailability, and ameliorate controlled release of the nano-encapsulated phenolic compounds.

中文翻译：

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通过将酚类化合物装载在基于脂质的纳米载体中来提高其生物利用度

背景

酚类化合物¹是食品和制药行业中最主要的营养保健品之一。酚醛树脂的应用由于其低生物利用度，低溶解度，低稳定性和非目标释放而受到限制。这些局限性可以通过新颖的“基于脂质的纳米封装技术”来克服，该技术能够向食品提供适当的针对性递送功能。

范围和方法

在这篇综述中，已经考虑和讨论了用于酚类的基于脂质的纳米载体的制备，应用和表征，包括纳米乳液，纳米级磷脂和纳米结构脂质载体。还已经考虑了纳米囊封酚类产品的生物利用度及其生产功能性食品的能力。

主要发现和结论

在食品和营养食品工业中，将酚类化合物装载到纳米载体中的主要目的是掩盖其口服给药所不希望的风味，提供高稳定性和高吸收性以及在胃肠道（GIT）条件下更好地释放。与微型载体相比，基于脂质制剂的纳米胶囊具有更大的表面积，并具有增强溶解度，提高生物利用度和改善纳米胶囊化合物的控制释放的潜力。