Interaction of Na+, K+, Mg2+ and Ca2+ counter cations with RNA,Metallomics

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Interaction of Na+, K+, Mg2+ and Ca2+ counter cations with RNA
Metallomics ( IF 2.9 ) Pub Date : 2018-04-11 00:00:00 , DOI: 10.1039/c8mt00043c
Stefan K. Kolev _{1,

2,

3,

4} , Petko St. Petkov _{4,

5,

6,

7} , Miroslav A. Rangelov _{2,

4,

8,

9,

10} , Dimitar V. Trifonov _{4,

11,

12,

13} , Teodor I. Milenov _{1,

2,

3,

4} , Georgi N. Vayssilov _{4,

5,

6,

7}

Affiliation

Alkaline and alkaline earth ions, namely Na⁺, K⁺, Mg²⁺ and Ca²⁺, are critical for the stability, proper folding and functioning of RNA. Moreover, those metal ions help to facilitate macromolecular interactions as well as the formation of supramolecular structures (e.g. the ribosome and the ribozymes). Therefore, identifying the interactions between ions and nucleic acids is a key to the better comprehension of the physical nature and biological functions of those biomolecules. The scope of this review is to highlight the preferential location and binding sites of alkaline and alkaline earth metal ions compensating the negatively charged backbone of nucleic acids and interacting with other electronegative centers, focusing on RNA. We summarize experimental studies from X-ray crystallography and spectroscopic analysis (infrared, Raman and NMR spectroscopies). Computational results obtained with classical and ab initio methods are presented afterwards.

中文翻译：

Na ⁺，K ⁺，Mg ²⁺和Ca ²⁺抗衡阳离子与RNA的相互作用

碱性和碱土金属离子，即Na ⁺，K ⁺，Mg ²⁺和Ca ²⁺，对于RNA的稳定性，正确折叠和功能至关重要。此外，那些金属离子有助于促进大分子相互作用以及超分子结构的形成（例如核糖体和核酶）。因此，鉴定离子与核酸之间的相互作用是更好地理解这些生物分子的物理性质和生物学功能的关键。本文的重点是强调碱和碱土金属离子的优先位置和结合位点，以补偿核酸的负电荷主链并与其他负电性中心相互作用，重点是RNA。我们总结了来自X射线晶体学和光谱分析（红外，拉曼光谱和NMR光谱学）的实验研究。随后介绍用经典方法和从头算方法获得的计算结果。

更新日期：2018-04-11

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