Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.

中文翻译：

---

肝素诱导的tau细丝在结构上是异质的，与阿尔茨海默氏病细丝不同†

阿尔茨海默氏病（AD）的特征是大脑中存在tau细丝，其结构最近已被解决。通常通过在体外将tau与肝素混合来模拟AD细丝的形成。这项研究表明，肝素诱导的tau细丝与AD细丝明显不同，并且异质性很高。