Controllable Formation of Monodisperse Polymer Microbubbles as Ultrasound Contrast Agents,ACS Applied Materials & Interfaces

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Controllable Formation of Monodisperse Polymer Microbubbles as Ultrasound Contrast Agents
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-11 00:00:00 , DOI: 10.1021/acsami.7b17258
Ruyuan Song , Chuan Peng ₁ , Xiaonan Xu , Jianwei Wang ₁ , Miao Yu , Youmin Hou , Ruhai Zou ₁ , Shuhuai Yao

Affiliation

Microbubbles have been widely used as ultrasound contrast agents in clinical diagnosis and hold great potential for ultrasound-mediated therapy. However, polydispersed population and short half-life time (<10 min) of the microbubbles still limit their applications in imaging and therapy. To tackle these problems, we develop a microfluidic flow-focusing approach to produce monodisperse microbubbles stabilized by Poly(lactic-co-glycolic acid) (PLGA) as the polymer shell. The size of PLGA microbubbles can be tightly controlled from ∼600 nm to ∼7 μm with a coefficient of variation less than 4% in size distribution for ensuring highly homogeneous echogenic behavior of PLGA polymer microbubbles in ultrasound fields. Both in vitro and in vivo experiments showed that the monodisperse PLGA microbubbles had excellent echogenicity and elongated sonographic duration time (>3 times) for ultrasound imaging in comparison with the commercial lipid microbubbles.

中文翻译：

可控制地形成单分散聚合物微泡作为超声造影剂

微泡在临床诊断中已广泛用作超声造影剂，并在超声介导的治疗中具有巨大潜力。但是，微泡的多分散种群和短的半衰期（<10分钟）仍然限制了它们在成像和治疗中的应用。为了解决这些问题，我们开发了一种微流聚焦方法，以生产以聚乳酸-乙醇酸（PLGA）为聚合物壳的单分散微泡。PLGA微泡的大小可以严格控制在〜600 nm至〜7μm之间，尺寸分布的变化系数小于4％，以确保PLGA聚合物微泡在超声场中具有高度均匀的回声特性。

更新日期：2018-04-11

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