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NIR-to-NIR Deep Penetrating Nanoplatforms Y2O3:Nd3+/Yb3+@SiO2@Cu2S toward Highly Efficient Photothermal Ablation
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-11 00:00:00 , DOI: 10.1021/acsami.8b03239 Zhiyu Zhang 1 , Hao Suo 1 , Xiaoqi Zhao 1 , Dan Sun 1 , Li Fan 2 , Chongfeng Guo 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-04-11 00:00:00 , DOI: 10.1021/acsami.8b03239 Zhiyu Zhang 1 , Hao Suo 1 , Xiaoqi Zhao 1 , Dan Sun 1 , Li Fan 2 , Chongfeng Guo 1
Affiliation
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A difunctional nano-photothermal therapy (PTT) platform with near-infrared excitation to near-infrared emission (NIR-to-NIR) was constructed through core–shell structures Y2O3:Nd3+/Yb3+@SiO2@Cu2S (YRSC), in which the core Y2O3:Nd3+/Yb3+ and shell Cu2S play the role of bioimaging and photothermal conversion function, respectively. The structure and composition of the present PTT agents (PTAs) were characterized by powder X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectra. The NIR emissions of samples in the biological window area were measured by photoluminescence spectra under the excitation of 808 nm laser; further, the penetration depth of NIR emission at different wavelengths in biological tissue was also demonstrated by comparing with visible (vis) emission from Y2O3:Yb3+/Er3+@SiO2@Cu2S and NIR emission from YRSC through different injection depths in pork muscle tissues. The photo-thermal conversion effects were achieved through the outer ultrasmall Cu2S nanoparticles simultaneously absorb NIR light emission from the core Y2O3:Nd3+/Yb3+ and the 808 nm excitation source to generate heat. Further, the heating effect of YRSC nanoparticles was confirmed by thermal imaging and ablation of YRSC to Escherichia coli and human hepatoma (HepG-2) cells. Results indicate that the YRSC has potential applications in PTT and NIR imaging in biological tissue.
中文翻译：
NIR到NIR的深穿透纳米平台Y 2 O 3：Nd 3+ / Yb 3+ @SiO 2 @Cu 2 S朝向高效光热消融
通过核-壳结构Y 2 O 3：Nd 3+ / Yb 3+ @SiO 2 @构建了具有近红外激发到近红外发射（NIR-to-NIR）的双功能纳米光热疗法（PTT）平台。Cu 2 S（YRSC），其中芯Y 2 O 3：Nd 3+ / Yb 3+和壳Cu 2S分别起到生物成像和光热转换功能的作用。通过粉末X射线衍射，场发射扫描电子显微镜，透射电子显微镜和X射线光电子能谱表征本发明PTT试剂（PTA）的结构和组成。在808nm激光的激发下，通过光致发光光谱测量生物窗口区域中样品的近红外发射。此外，还通过与Y 2 O 3：Yb 3+ / Er 3+ @SiO 2 @Cu 2的可见（可见）发射进行比较，证明了生物组织中不同波长的NIR发射的穿透深度。通过猪肉肌肉组织中不同的注入深度，YRSC产生的S和NIR发射。通过外部超小Cu 2 S纳米粒子同时吸收来自核心Y 2 O 3：Nd 3 + / Yb 3+和808 nm激发源的NIR发光产生热量，从而实现了光热转换效果。此外，YRSC纳米颗粒的热效应通过热成像和YRSC对大肠杆菌和人肝癌（HepG-2）细胞的消融证实。结果表明，YRSC在生物组织的PTT和NIR成像中具有潜在的应用。
更新日期：2018-04-11
中文翻译：
NIR到NIR的深穿透纳米平台Y 2 O 3：Nd 3+ / Yb 3+ @SiO 2 @Cu 2 S朝向高效光热消融
通过核-壳结构Y 2 O 3：Nd 3+ / Yb 3+ @SiO 2 @构建了具有近红外激发到近红外发射（NIR-to-NIR）的双功能纳米光热疗法（PTT）平台。Cu 2 S（YRSC），其中芯Y 2 O 3：Nd 3+ / Yb 3+和壳Cu 2S分别起到生物成像和光热转换功能的作用。通过粉末X射线衍射，场发射扫描电子显微镜，透射电子显微镜和X射线光电子能谱表征本发明PTT试剂（PTA）的结构和组成。在808nm激光的激发下，通过光致发光光谱测量生物窗口区域中样品的近红外发射。此外，还通过与Y 2 O 3：Yb 3+ / Er 3+ @SiO 2 @Cu 2的可见（可见）发射进行比较，证明了生物组织中不同波长的NIR发射的穿透深度。通过猪肉肌肉组织中不同的注入深度，YRSC产生的S和NIR发射。通过外部超小Cu 2 S纳米粒子同时吸收来自核心Y 2 O 3：Nd 3 + / Yb 3+和808 nm激发源的NIR发光产生热量，从而实现了光热转换效果。此外，YRSC纳米颗粒的热效应通过热成像和YRSC对大肠杆菌和人肝癌（HepG-2）细胞的消融证实。结果表明，YRSC在生物组织的PTT和NIR成像中具有潜在的应用。
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