Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored.

The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyperlipidemia in 57BL/6 J mice.

Obesity associated insulin resistance was induced by continuously feeding the mice with high-fat diet for 10 weeks. Afterwards, mice were subjected to intragastric administration of herbacetin (different doses) daily along with high-fat diet for the next 5 weeks. At the end of 106^th day, changes in body weight, blood glucose, insulin, HOMA-IR, and lipids profiles and lipid-regulating enzymes were evaluated.

Herbacetin significantly reduced the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). In addition, herbacetin administration significantly reduced the plasma and hepatic total cholesterol, triglycerides, and free fatty acids in OIR mice. Moreover, herbacetin significantly improved the altered hepatic lipid metabolizing and lipid-regulating enzymes such as SREBP-1c, and 2, fatty acid synthase (FAS), fatty acid β-oxidation (β-oxidation), malic enzyme, glucose 6-phosphate dehydrogenase (G6PD), and carnitine palmitoyltransferase (CPT) when compared to OIR control mice. Histopathological examination clearly showed that herbacetin decreases lipid droplets in the liver tissue.

Thus, observed results strongly indicate that herbacetin provides remarkable protection against the harmful effects of chronic high-fat diet consumption because of its anti-hyperglycaemic and anti-hyperlipidemic properties through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes.

健康的植物及其成分被认为是治疗肥胖症和肥胖症相关疾病的安全药物。草精素是一种饮食类黄酮，已被研究用于许多药理活性。但是，尚未研究除草素的抗高血糖和抗高血脂的特性。

进行本研究以评估除草素对高脂饮食诱导的57BL / 6 J小鼠高血糖和高脂血症的改善作用。

肥胖相关的胰岛素抵抗是通过连续喂养高脂饮食10周来诱导的。之后，在接下来的5周中，每天对小鼠进行胃内注射草胺西汀（不同剂量）以及高脂饮食。在106处的端部^第一天，改变体重，血糖，胰岛素，HOMA-IR，和脂质概况和脂质调节的酶进行了评价。

在肥胖症相关的胰岛素抵抗小鼠（OIR）中，草精蛋白显着降低了体重，血浆葡萄糖，血浆胰岛素和HOMA-IR活性。另外，除草素的给药显着降低了OIR小鼠的血浆和肝脏总胆固醇，甘油三酸酯和游离脂肪酸。此外，除草素可以显着改善改变的肝脂质代谢和脂质调节酶，如SREBP-1c和2，脂肪酸合酶（FAS），脂肪酸β-氧化（β-氧化），苹果酸酶，葡萄糖6-磷酸脱氢酶（G6PD）和肉碱棕榈酰转移酶（CPT）与OIR对照小鼠相比。组织病理学检查清楚地表明，草精蛋白减少了肝脏组织中的脂质滴。

因此，观察到的结果有力地表明，除草素可通过调节肝脂质代谢和脂质调节酶的抗高血糖和抗高血脂特性，从而为长期食用高脂饮食的有害作用提供了显着的保护作用。