Oxidative damage of DNA has recently been indicated as one of the strong pathogenic agent in Alzheimer’s disease (AD). Oxidative stress induces numerous signaling pathways, including DNA damage response (DDR), associated with the breast cancer type 1 susceptibility protein (BRCA1) protein, known to date from numerous reports in the cancer field. In this Viewpoint, we discuss the latest discoveries related to the role of BRCA1 in the death of neurons in AD. We underline the role of BRCA1 in the development of neurons and speculate on the consequences of BRCA1 dysfunction in the dying brain. In general, this Viewpoint is in a line with several recent reports on the processes and players common at the molecular and genetic level for neurodegenerative and cancerous diseases.

中文翻译：

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BRCA1在阿尔茨海默氏病神经元死亡中的作用

最近，DNA的氧化损伤被认为是阿尔茨海默氏病（AD）的强致病原体之一。氧化应激诱导了许多信号通路，包括与1型乳腺癌易感性蛋白质（BRCA1）蛋白质相关的DNA损伤反应（DDR），迄今为止在癌症领域的许多报道中都已知道。在这种观点下，我们讨论与BRCA1在AD神经元死亡中的作用有关的最新发现。我们强调了BRCA1在神经元发育中的作用，并推测了垂死的大脑中BRCA1功能障碍的后果。总体而言，该观点与关于神经退行性疾病和癌性疾病在分子和遗传水平上常见的过程和参与者的最新报道相一致。