Polycationic dendrimers were generated through simple and versatile reversible amine/aldehyde-imine chemistry. The inherent CD spectroscopic signal arising from the helical structures of single-stranded DNA (ssDNA) undergoes a dramatic amplification in the presence of the synthesised polycationic dendrimers. Compared to the first-generation core molecule, the second-generation dendrimer shows high spectroscopic responses upon chiral recognition of short ssDNA, owing to the combination of self-assembly and multivalency effects. The maximum signal variation is reached at the molar ratio at which the ratio between the negative charges in ssDNA balance the positive charges of the dendrimers, thus the approach enables differential recognition of ssDNAs of different lengths. Altogether, these results accelerate the simple and systematic discovery of efficient adaptive molecules for biomimetic recognition of ssDNA with high accuracy.

中文翻译：

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各种长度和序列的短单链DNA的多价树状聚合物及其差异识别。

聚阳离子树状聚合物是通过简单且通用的可逆胺/醛-亚胺化学方法生成的。在合成的聚阳离子树枝状大分子存在下，由单链DNA（ssDNA）的螺旋结构产生的固有CD光谱信号会急剧扩增。与第一代核心分子相比，第二代树状聚合物由于自组装和多价效应的结合，在短手性ssDNA的手性识别后显示出高光谱响应。在ssDNA中的负电荷之间的比例与树状聚合物的正电荷平衡的摩尔比下达到最大信号变化，因此该方法可以区分不同长度的ssDNA。共，