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Efficient Suzuki-Miyaura mono-arylation of symmetrical diiodo(hetero)arenes
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-04-10 , DOI: 10.1016/j.tetlet.2018.04.015
Alexander Sapegin , Mikhail Krasavin

A reliable protocol for converting 1,4-diiodo-2,3,5,6-tetrafluorobenzene into 1-(hetero)aryl-4-iodo-2,3,5,6-tetrafluorobenzene derivatives has been lacking in the literature. We have identified optimal conditions to achieve this conversion in good yields and have minimized formation of the bis-coupling product. The newly identified protocol involving the use of a syringe pump has been extended to other symmetrical diiodo(hetero)arenes.



中文翻译:

对称二碘(杂)芳烃的高效Suzuki-Miyaura单芳基化

文献中缺乏将1,4-二碘-2,3,5,6-四氟苯转化成1-(杂)芳基-4-碘-2,3,5,6-四氟苯衍生物的可靠方案。我们已经确定了最佳条件,可以实现高收率的这种转化,并最大程度地减少了双偶合产物的形成。新近确定的涉及使用注射泵的方案已扩展到其他对称的二碘(杂)芳烃。

更新日期:2018-04-10
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