Resveratrol, a natural polyphenol widely applauded for its cardio-protective and anti-cancer activity, has limited application due to its poor solubility and low bioavailability. Hence, an attempt was made to optimize the preparation of biocompatible resveratrol loaded niosomes (R-niosomes) using non-ionic surfactants and fatty alcohol as stabilizer employing the novel and green method of sonication. R-niosomes exhibited mean particle size of 108 nm with narrow size distribution (PDI = 0.24) and high zeta potential (−56.8 mV). The niosomes had >80% of resveratrol encapsulated into the vesicles and exhibited controlled release under simulated gastro-intestinal conditions. FTIR, XRD and DSC analyses confirmed successful encapsulation of resveratrol into the vesicles. Assays in macrophage RAW264.7 cell lines showed that R-niosomes had lower cytotoxicity and higher intracellular ROS scavenging activity when compared to resveratrol in its free form. This study demonstrated that nanoencapsulation of resveratrol through niosomes using non-ionic surfactant and fatty alcohol has dramatically improved its solubility and functionality.

白藜芦醇是一种天然的多酚，因其心脏保护和抗癌活性而广受赞誉，但由于其溶解性差和生物利用度低而受到限制。因此，尝试使用新型和绿色的超声处理方法，以非离子表面活性剂和脂肪醇为稳定剂，优化生物相容性负载白藜芦醇的脂质体（R-脂质体）的制备。R-核糖体的平均粒径为108 nm，粒径分布较窄（PDI = 0.24），ζ电位较高（-56.8 mV）。所述脂质体具有＞ 80％的白藜芦醇封装在囊泡中，并且在模拟胃肠条件下表现出受控释放。FTIR，XRD和DSC分析证实白藜芦醇已成功封装到囊泡中。在巨噬细胞RAW264中进行测定。7种细胞系显示，与游离形式的白藜芦醇相比，R-核糖体具有较低的细胞毒性和较高的细胞内ROS清除活性。这项研究表明，使用非离子表面活性剂和脂肪醇通过脂质体通过纳米脂质体对白藜芦醇进行纳米囊封可以显着改善其溶解度和功能。