A concise total synthesis of cochlearoid B†,Organic & Biomolecular Chemistry

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A concise total synthesis of cochlearoid B†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-04-10 00:00:00 , DOI: 10.1039/c8ob00615f
Wuxia Zhang _{1,

2,

3,

4,

5} , Dehai Xiao _{1,

2,

3,

4,

5} , Bo Wang _{1,

2,

3,

4,

5}

Affiliation

A T-type calcium channel inhibiting natural product cochlearoid B was synthesized for the first time in 7 linear steps via a convergent strategy exploiting the Suzuki–Miyaura cross coupling and the acid promoted Prins cyclization cascade. This strategy allows rapid access to its structural analogues for further therapeutical development.

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