A convenient approach to the synthesis of diverse difluorinated nitrogen‐containing polycycles via a copper‐catalyzed radical cascade annulation of amine‐containing olefins and ethyl bromodifluoroacetate was developed. Three new bonds, including a −CF₂ and two C−N bonds, are forged simultaneously in this strategy. Through this strategy, a series of difluorinated pyrrolizidine and indolizidine derivatives have been conveniently synthesized in good yields.

中文翻译：

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通过铜催化的自由基级联环流法一锅构建二氟吡咯烷和吲哚并立支架

通过铜催化含胺烯烃和溴代二氟乙酸乙酯的自由基级联环合反应，开发了一种简便的合成多种二氟含氮多环化合物的方法。在此策略中同时伪造了三个新的债券，包括 -CF ₂和两个C-N债券。通过这种策略，已经方便地以高收率合成了一系列二氟吡咯烷啶和吲哚唑烷衍生物。