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Microwave promoted reaction of purin-6-yl magnesium halides with aldehydes in dichloromethane at 100 °C
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-04-10 , DOI: 10.1016/j.tetlet.2018.04.014
Malcolm R. Gordon , Stephen D. Lindell

Treatment of a dichloromethane solution of 9-benzyl or 9-phenyl 6-iodopurine with ethereal ethylmagnesium bromide at ambient temperature gives the corresponding purin-6-yl magnesium halides. Addition of an aldehyde followed by heating at 100 °C in a microwave reactor yielded the corresponding carbinols in 52–81% yield.



中文翻译:

在100°C下微波促进嘌呤-6-基卤化镁与醛在二氯甲烷中的反应

在环境温度下用乙基乙基溴化镁处理9-苄基或9-苯基6-碘嘌呤的二氯甲烷溶液,得到相应的嘌呤-6-基卤化镁。添加醛,然后在微波反应器中于100°C加热,得到相应的甲醇,收率为52–81%。

更新日期:2018-04-10
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