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Synergistic effect of caffeic acid phenethyl ester with caspofungin against Candida albicans is mediated by disrupting iron homeostasis
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2018-04-07
Lingmei Sun, Chengcheng Hang, Kai Liao

Highlights

CAPE and CAS combination has a synergistic effect against C. albicans.

CAPE treatment induces the perturbation of iron homeostasis in C. albicans.

CAPE treatment decreases the mitochondrial respiration and increases ROS generation.

CAPE potentiates the antifungal activities of CAS via mitochondrial dysfunction.



中文翻译:

咖啡酸苯乙酯与卡泊芬净对白念珠菌的协同作用是通过破坏铁稳态而介导的

强调

CAPE和CAS的结合对白色念珠菌具有协同作用

CAPE处理在白色念珠菌中引起铁稳态的扰动

CAPE处理可降低线粒体呼吸并增加ROS的产生。

CAPE通过线粒体功能障碍增强CAS的抗真菌活性。

更新日期:2018-04-08
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