Reservoirs play more and more important role in providing potable water in many developing countries, including the China. In the present study, pollution characteristics, source and health risk of dissolved heavy metals in 19 representative reservoirs in the hilly area of southern China were investigated. The results presented great spatial heterogeneity in heavy metal concentrations among the studied reservoirs due to the disturbances by different anthropogenic activities. Several reservoirs had significantly higher concentrations of heavy metals compared with others, FengTan (FT) reservoir (0.34 μg/L in dry season), Cr in reservoirs of HuangShi (HS) and ZheLin (ZL) with values of 4.16 μg/L and 3.45 μg/L in dry season respectively, and Al in reservoirs of JiaoKou (JK), GuTian (GT) and DouShui (DS) with values of 1011 μg/L, 1036 μg/L and 1001 μg/L in wet season, respectively. Furthermore, there was a great difference in the seasonal variation of heavy metals, especially for Al and Pb in wet season characterized with relatively high values of 643 μg/L and 0.67 μg/L, respectively. Accordingly, Al was identified with a great health risk to living beings in view of its mean value in wet season, which greatly exceeded the criteria for drinking water of China, WHO and US EPA. Furthermore, As might be the greatest concern of health risk in this region considering its high carcinogenic risk to the local residents around the reservoirs of OuYangHai (OYH), DS, ZhiXi (ZX) and HS. Multivariate statistical analysis suggested that there was great heterogeneity in the sources of these heavy metals in the hilly area of southern China. Therefore, specific measures, such as controls on point source pollution control and tailings, should be taken for maintaining drinking water safety and aquatic ecosystem health.