Tetraspanins are a family of proteins largely expressed in mammals. These proteins share very similar structures and are involved in several biological processes spanning from the immune system to cancer growth regulation. Moreover, tetraspanins are scaffold proteins that are able to interact with each other and with a subset of proteins involved in the regulation of the central nervous system, including synapse formation, function and plasticity.

In this review, we will focus on the analysis of the literature on tetraspanins, highlighting their involvement in synapse formation and function through direct or indirect modulation of synaptic proteins.

中文翻译：

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四跨膜蛋白塑造突触

四跨膜蛋白是在哺乳动物中大量表达的蛋白质家族。这些蛋白质具有非常相似的结构，并参与从免疫系统到癌症生长调节的多个生物学过程。此外，四跨膜蛋白是支架蛋白，它们能够彼此相互作用，并且能够与参与中枢神经系统调节（包括突触形成，功能和可塑性）的一部分蛋白相互作用。

在这篇综述中，我们将专注于对四跨素的文献分析，强调它们通过直接或间接调节突触蛋白来参与突触形成和功能。