Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription factor that is known to be ligand activated. Early AhR studies focused on understanding the role of AhR in mediating the toxicity and carcinogenesis properties of the prototypic ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In recent years, however, it has become apparent that, in addition to its toxicological involvement, AhR is highly receptive to a wide array of endogenous and exogenous ligands, and that its activation leads to a myriad of key host physiological functions. In this study, we review the current understanding of the functions of AhR in the mucosal immune system with a focus on its role in intestinal barrier function and intestinal immune cells, as well as in intestinal homeostasis.

中文翻译：

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芳烃受体与肠道免疫。

芳基烃受体 (AhR) 是转录因子基本螺旋-环-螺旋-(bHLH) 超家族的成员，它与细胞对环境刺激（例如异生素和氧气水平）的反应有关。与 bHLH 的其他成员不同，AhR 是唯一已知被配体激活的 bHLH 转录因子。早期的 AhR 研究侧重于了解 AhR 在介导原型配体 2,3,7,8-四氯二苯并二恶英 (TCDD) 的毒性和致癌特性中的作用。然而，近年来，很明显，除了其毒理学参与外，AhR 还高度接受各种内源性和外源性配体，并且其激活导致无数关键的宿主生理功能。在这项研究中，