Well-defined oligo- and polysaccharides as ideal probes for structural studies,Journal of the American Chemical Society

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Well-defined oligo- and polysaccharides as ideal probes for structural studies
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-04-06 , DOI: 10.1021/jacs.8b00254
Martina Delbianco ₁ , Andrew Kononov _{1,

2} , Ana Poveda ₃ , Yang Yu _{1,

2} , Tammo Diercks ₃ , Jesús Jiménez-Barbero ₃ , Peter H. Seeberger _{1,

2}

Affiliation

Polysaccharides are the most abundant organic materials in nature, yet correlations between their three-dimensional structure and macroscopic properties have not been established. Automated glycan assembly enables the preparation of well-defined oligo- and polysaccharides resembling natural as well as unnatural structures. These synthetic glycans are ideal probes for the fundamental study of polysaccharides. According to molecular modeling simulations and NMR analysis, different classes of polysaccharides adopt fundamentally different conformations that are drastically altered by single-site substitutions. Larger synthetic polysaccharides are obtained via a "LEGO"-like approach as a first step toward the production of tailor-made carbohydrate-based materials.

中文翻译：

定义明确的寡糖和多糖是结构研究的理想探针

多糖是自然界中含量最丰富的有机物质，但其三维结构与宏观特性之间的相关性尚未确定。自动化聚糖组装能够制备类似于天然和非天然结构的明确定义的寡糖和多糖。这些合成聚糖是多糖基础研究的理想探针。根据分子建模模拟和 NMR 分析，不同类别的多糖采用根本不同的构象，这些构象因单位点取代而发生巨大变化。更大的合成多糖是通过类似于“乐高”的方法获得的，这是生产定制碳水化合物基材料的第一步。

更新日期：2018-04-06

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