We aimed to determine the effects of Lactobacillus strains against rotaviral infections. Rotaviruses are the major causative agent of acute gastroenteritis in infants and children worldwide. However, to date, no specific antiviral drugs for the treatment of rotavirus infection have been developed. We identified 263 Lactobacillus strains from 35 samples of the traditional Korean fermented vegetable food, kimchi. Among them, Lactobacillus plantarum LRCC5310, more specifically the exopolysaccharides produced by these cells, were shown to have an antiviral effect against human rotavirus Wa strain in vitro. In vivo, the oral administration of exopolysaccharides for 2 d before and 5 d after mouse infection with the murine rotavirus epidemic diarrhea of infant mice strain led to a decrease in the duration of diarrhea and viral shedding and prevented the destruction of enteric epithelium integrity in the infected mice. We demonstrated here that the exopolysaccharides extracted from L. plantarum LRCC5310 can be used for the effective control of rotavirus infection.

我们旨在确定乳杆菌菌株对轮状病毒感染的影响。轮状病毒是全世界婴儿和儿童急性胃肠炎的主要病原体。然而，迄今为止，尚未开发出用于治疗轮状病毒感染的特异性抗病毒药。我们从35个传统的韩国发酵蔬菜食品泡菜样品中鉴定了263株乳酸杆菌。其中，植物乳杆菌LRCC5310，更具体地说是这些细胞产生的胞外多糖，在体外对人轮状病毒Wa株具有抗病毒作用。在体内，在小鼠感染鼠轮状病毒流行性腹泻的小鼠感染小鼠之前2天和口服之后5天口服外多糖导致腹泻和病毒脱落的持续时间减少，并防止了肠道中肠上皮完整性的破坏。被感染的小鼠。我们在这里证明，从植物乳杆菌LRCC5310提取的胞外多糖可用于有效控制轮状病毒感染。