Stability of metal-organic frameworks (MOFs) in aqueous medium and extreme solution conditions (acidic or basic) are important for the development of stable, reproducible, and sensitive electrochemical biosensors. Herein, a base-stable chromium(III) dicarboxylate MOF was synthesized by microwave assisted solvothermal method for non-enzymatic detection of hydrogen peroxide (H₂O₂). The as-synthesized MOF exhibited excellent base stability without any obvious changes in crystallinity, morphology, and spectroscopic behaviors after base treatment. This MOF-modified glassy carbon electrode showed negligible change in charge transfer resistance at the electrode|electrolyte interface after redox cycling and good catalytic activity for the reduction of H₂O₂ in 0.1 M NaOH_(aq.). The enhanced catalytic activity of H₂O₂ reduction is enabled by the redox process of Cr^III/II in the chromium (III) dicarboxylate. The sensor showed the sensitivity of ca. 11.9 μA mM⁻¹, wide linear range from 25 to 500 μM, and a method detection limit of ca. 3.52 μM. The validation of this sensing platform was evaluated by standard addition method. Thus, the present biosensor could be used for the point of care detection of H₂O₂.

金属有机骨架（MOF）在水性介质和极端溶液条件（酸性或碱性）下的稳定性对于开发稳定，可重现和敏感的电化学生物传感器至关重要。在此，通过微波辅助溶剂热法合成了碱稳定的二羧酸三价铬（MO），用于非酶法检测过氧化氢（H ₂ O ₂）。合成后的MOF表现出优异的碱稳定性，碱处理后结晶度，形态和光谱行为没有明显变化。该MOF改性的玻璃碳电极在氧化还原循环后，在电极界面的电荷转移电阻的变化可忽略不计，且对于H ₂ O的还原具有良好的催化活性。₂在0.1 M NaOH _{（水溶液）中}。通过二羧酸铬（III）中的Cr ^{III / II}的氧化还原过程，可以提高H ₂ O ₂还原的催化活性。传感器显示出约3的灵敏度。11.9μAmM ^-1，线性范围从25到500μM，方法检测极限为。3.52微米 该感测平台的验证通过标准添加方法进行评估。因此，本生物传感器可以用于H ₂ O ₂的即时检测。