The toxic effects of Ochratoxin A (OTA), a fungal secondary metabolite of the genera Aspergillus and Penicillium with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) a Parkinson inducing drug were investigated to evaluate the neurotoxic effects exerted by OTA. OTA is known to contaminate food and feedstuff leading to a wide range of toxicity like nephrotoxicity, hepatotoxicity, and immunotoxicity. However, due to the dearth of available information on the possible mechanisms of OTA neurotoxicity and neurodegeneration the current study was undertaken. Hence, in this study, we examined the neurotoxic effects and the possible mechanism of action of neurodegeneration by OTA toxicity on mice brain by conducting a battery of behavioural studies and reviewing neurotransmitter levels and neuronal apoptotic pathways. Further, they were treated with l-Dopa, a precursor of dopamine (DA) to explore its ameliorative effects against OTA. The results of behavioural studies like gait analysis, spontaneous activity, cylinder test and pole test showed that OTA exhibits Parkinsonian physiognomies which were stabilized with l-Dopa treatment. Also, OTA toxicity showed insults on neurotransmitter levels and general brain function parameters that were normalized with l-Dopa treatment. The results of the present study suggest that OTA promotes neurodegeneration by targeting neuronal pathway leading to the development of Parkinson's diseases.

赭曲霉毒素A的毒性作用（OTA），该属的真菌次级代谢产物曲霉和青霉与1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）一起使用，研究了帕金森诱导药物，以评估OTA发挥的神经毒性作用。众所周知，OTA会污染食品和饲料，导致广泛的毒性，如肾毒性，肝毒性和免疫毒性。但是，由于缺乏有关OTA神经毒性和神经变性的可能机制的可用信息，因此进行了本研究。因此，在这项研究中，我们通过进行一系列行为研究并审查了神经递质水平和神经元凋亡途径，研究了OTA毒性对小鼠大脑的神经毒性作用和可能的神经退行性作用机制。此外，他们与治疗升-多巴胺（Dopa），多巴胺（DA）的前体，以探索其对OTA的改善作用。步态分析，自发活动，圆柱体测试和极点测试等行为研究的结果表明，OTA表现出帕金森氏生理，并通过l -Dopa处理得以稳定。同样，OTA毒性显示出对神经递质水平和一般脑功能参数的侮辱，这些参数已通过1- Dopa治疗进行了标准化。本研究的结果表明，OTA通过靶向导致帕金森氏病发展的神经元通路来促进神经变性。