A Concise Approach to Anthraquinone-Xanthone Heterodimers,Journal of the American Chemical Society

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A Concise Approach to Anthraquinone-Xanthone Heterodimers
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-04-05 , DOI: 10.1021/jacs.8b03110
Stephen D. Holmbo ₁ , Sergey V. Pronin ₁

Affiliation

A synthetic approach to anthraquinone-xanthone heterodimers is described. The route to the pentacyclic core features an efficient assembly of a benzocycloheptenone via a new intramolecular oxidative arylation of an enol ether and a Hauser-Kraus annulation-aldol reaction sequence to access the characteristic bicyclo[3.2.2]nonene motif. Acremoxanthone A is synthesized in 10 steps from commercially available material to demonstrate the application of this approach.

中文翻译：

蒽醌-氧杂蒽酮异二聚体的简明方法

描述了蒽醌-氧杂蒽酮异二聚体的合成方法。通往五环核心的路线的特点是通过烯醇醚的新分子内氧化芳基化和 Hauser-Kraus 环化-羟醛反应序列有效组装苯并环庚烯酮，以获取特征性双环 [3.2.2] 壬烯基序。Acremoxanthone A 是从市售材料中分 10 个步骤合成的，以证明这种方法的应用。

更新日期：2018-04-05

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