Oncogene-induced cellular senescence (OIS) is a complex program that is triggered in response to aberrant activation of oncogenic signaling. Initially, OIS was thought to be a barrier to malignant transformation because of its suppression on cell proliferation. Later studies showed that senescence induced by oncogenes can also promote the initiation and development of cancer. The opposing effects of OIS occur through different combinations of downstream effectors as well as the interplay of senescent cells and the microenvironment, such as senescence-associated inflammation. Here, we review the common features and molecular mechanisms underlying OIS and the interaction between senescent cells and the microenvironment. We propose that targeting senescent cells may have a beneficial therapeutic effect during the treatment of cancer.

中文翻译：

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癌基因诱导的衰老：癌症的双刃剑。

癌基因诱导的细胞衰老（OIS）是一个复杂的程序，可响应致癌信号的异常激活而触发。最初，由于OIS抑制了细胞增殖，因此被认为是恶性转化的障碍。后来的研究表明，癌基因诱导的衰老也可以促进癌症的发生和发展。OIS的相反作用是通过下游效应物的不同组合以及衰老细胞与微环境的相互作用（例如衰老相关的炎症）而发生的。在这里，我们回顾了OIS的共同特征和分子机制以及衰老细胞与微环境之间的相互作用。我们建议靶向衰老的细胞可能在癌症的治疗过程中具有有益的治疗作用。