Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells†,Chemical Communications

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Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-04-04 00:00:00 , DOI: 10.1039/c8cc00977e
S. Ichikawa _{1,

2,

3,

4} , N. Shimokawa _{4,

5,

6,

7} , M. Takagi _{4,

5,

6,

7} , Y. Kitayama _{1,

2,

3,

4} , T. Takeuchi _{1,

2,

3,

4,

8}

Affiliation

Size-dependent uptake behaviors of electrically neutral amphipathic polymeric nanoparticles in cell-sized liposomes and living cells were investigated. Kinetic analyses and the particle size distribution suggested a size-dependent penetration mechanism (size threshold: 3.1 nm). The definite size-dependent uptake provides a new insight into the interactions between nanomaterials and living cells.

中文翻译：

细胞大小的脂质体对电中性两亲聚合物纳米粒子的大小依赖性吸收及其对活细胞内在化机理的了解†

研究了电中性两亲聚合物纳米粒子在细胞大小的脂质体和活细胞中的大小依赖性摄取行为。动力学分析和粒度分布表明了一种取决于尺寸的渗透机制（尺寸阈值：3.1 nm）。取决于大小的确定摄取为纳米材料与活细胞之间的相互作用提供了新的见解。

更新日期：2018-04-04

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