Moldable Perfluoropolyether–Polyethylene Glycol Networks with Tunable Wettability and Solvent Resistance for Rapid Prototyping of Droplet Microfluidics,Chemistry of Materials

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Moldable Perfluoropolyether–Polyethylene Glycol Networks with Tunable Wettability and Solvent Resistance for Rapid Prototyping of Droplet Microfluidics
Chemistry of Materials ( IF 7.2 ) Pub Date : 2018-04-04 00:00:00 , DOI: 10.1021/acs.chemmater.7b05043
Heon-Ho Jeong _{1,

2} , Syung Hun Han ₃ , Sagar Yadavali ₃ , Junhyong Kim ₄ , David Issadore _{1,

3,

5} , Daeyeon Lee ₁

Affiliation

Soft lithography-based droplet microfluidics has enabled production of highly uniform and complex emulsions. Although there is a significant potential to use these emulsions as templates for functional materials syntheses, conventional elastomers that are used for microfluidic device preparation are significantly deformed and swollen by various organic solvents, limiting the types of materials that can be processed using conventional soft lithography-based droplet microfluidics. In this report, we demonstrate that both water-in-oil and oil-in-water emulsion with organic solvents can be produced by using microfluidic devices that are prepared using cross-linked networks of perfluoropolyether (PFPE) and poly(ethylene glycol) diacrylate (PEGDA). We show that these PFPE–PEG networks are transparent and maintain excellent compatibility with various organic solvents. Importantly, the wettability of these devices can be systematically controlled by changing the ratio of the two macromonomers. By taking advantage of rapid prototyping and controlled surface wettability afforded by the PFPE–PEG network, we prepare three-dimensional monolithic elastomer devices for the parallel generation of oil-in-water and water-in-oil droplets. We also show that, using these devices, solid microparticles with high uniformity can be produced by using an organic solvent-based emulsion as a template. We believe the PFPE–PEG network will have broad impacts in the application of soft lithography-based elastomer microfluidic devices to a wide range of applications, including drug screening and solvent-based separation processes.

中文翻译：

具有可调节的润湿性和耐溶剂性的可模制全氟聚醚-聚乙二醇网络，可用于液滴微流体的快速原型制作

基于软光刻的液滴微流控技术能够生产高度均匀和复杂的乳液。尽管将这些乳液用作合成功能材料的模板具有巨大的潜力，但用于微流体装置制备的常规弹性体会因各种有机溶剂而显着变形和溶胀，从而限制了可使用常规软光刻技术处理的材料类型：基于液滴的微流体。在本报告中，我们证明了通过使用全氟聚醚（PFPE）和聚（乙二醇）二丙烯酸酯的交联网络制备的微流体装置，可以生产有机溶剂的油包水和水包油乳液（PEGDA）。我们表明，这些PFPE-PEG网络是透明的，并与各种有机溶剂保持出色的相容性。重要的是，可以通过改变两种大分子单体的比例来系统地控制这些装置的润湿性。通过利用PFPE-PEG网络提供的快速原型制作和可控制的表面润湿性，我们准备了三维整体式弹性体设备，用于并行生成水包油和油包水液滴。我们还表明，使用这些设备，可以通过使用基于有机溶剂的乳液作为模板来生产具有高均匀性的固体微粒。我们相信PFPE-PEG网络将对基于软光刻技术的弹性体微流控设备的广泛应用产生广泛的影响，

更新日期：2018-04-04

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