Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin,Nature

当前位置： X-MOL 学术 › Nature › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
Nature ( IF 50.5 ) Pub Date : 2018-04-01 , DOI: 10.1038/s41586-018-0010-9
Peng Zhou ₁ , Hang Fan ₂ , Tian Lan _{3,

4} , Xing-Lou Yang ₁ , Wei-Feng Shi ₅ , Wei Zhang ₁ , Yan Zhu ₁ , Ya-Wei Zhang ₂ , Qing-Mei Xie _{3,

4} , Shailendra Mani ₆ , Xiao-Shuang Zheng ₁ , Bei Li ₁ , Jin-Man Li ₂ , Hua Guo ₁ , Guang-Qian Pei ₂ , Xiao-Ping An ₂ , Jun-Wei Chen _{3,

4} , Ling Zhou _{3,

4} , Kai-Jie Mai _{3,

4} , Zi-Xian Wu _{3,

4} , Di Li _{3,

4} , Danielle E Anderson ₆ , Li-Biao Zhang ₇ , Shi-Yue Li ₈ , Zhi-Qiang Mi ₂ , Tong-Tong He ₂ , Feng Cong ₉ , Peng-Ju Guo ₉ , Ren Huang ₉ , Yun Luo ₁ , Xiang-Ling Liu ₁ , Jing Chen ₁ , Yong Huang ₂ , Qiang Sun ₂ , Xiang-Li-Lan Zhang ₂ , Yuan-Yuan Wang ₂ , Shao-Zhen Xing ₂ , Yan-Shan Chen _{3,

4} , Yuan Sun _{3,

4} , Juan Li ₅ , Peter Daszak ₁₀ , Lin-Fa Wang ₆ , Zheng-Li Shi ₁ , Yi-Gang Tong _{2,

11} , Jing-Yun Ma _{3,

4}

Affiliation

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Beijing Institute of Microbiology and Epidemiology, Beijing, China.
College of Animal Science, South China Agricultural University, Guangzhou, China.
Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.
Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.
School of Public Health, Wuhan University, Wuhan, China.
Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
EcoHealth Alliance, New York, NY, USA.
School of Life Sciences, North China University of Science and Technology, Tangshan, China.

Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1. Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2–10. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.

更新日期：2018-04-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11