Harnessing the Coordination Chemistry of 1,4,7-Triazacyclononane for Biomimicry and Radiopharmaceutical Applications.,ChemPlusChem

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Harnessing the Coordination Chemistry of 1,4,7-Triazacyclononane for Biomimicry and Radiopharmaceutical Applications.
ChemPlusChem ( IF 3.0 ) Pub Date : 2018-05-04 , DOI: 10.1002/cplu.201800103
Tanmaya Joshi ₁ , Manja Kubeil ₁ , Anne Nsubuga ₁ , Garima Singh ₁ , Gilles Gasser ₂ , Holger Stephan ₁

Affiliation

1,4,7-Triazacyclononane (TACN)-based mono- and poly-nuclear metal complexes have found extensive use as biological mimics for understanding the structural and operational aspects of complex natural systems. Their coordination flexibility has also provided researchers access to a vast library of radiometal-binding motifs that display excellent thermodynamic stability and kinetic inertness upon metal complexation. Synthetic modification of the TACN backbone has yielded ligands that can form metal complexes with coordination geometries well suited for these applications. In particular, Leone Spiccia's research has played a significant role in accelerating the progress in these two fields. With a focus on his contributions to the topics of biomimicry and radiopharmaceuticals, this Minireview uses relevant examples to put in perspective the utility of macrocyclic coordination chemistry for biological inorganic chemistry applications.

中文翻译：

利用1,4,7-三氮杂环壬烷的配位化学在仿生和放射性药物中的应用。

基于1,4,7-三氮杂双环壬烷（TACN）的单核和多核金属配合物已被广泛用作生物学模拟物，以了解复杂自然系统的结构和操作方面。它们的协调灵活性还为研究人员提供了一个庞大的放射性金属结合基元库，这些基元在金属络合时表现出出色的热力学稳定性和动力学惰性。TACN主链的合成修饰产生了配体，这些配体可以形成配位几何形状非常适合这些应用的金属络合物。特别是，Leone Spiccia的研究在加速这两个领域的进步方面发挥了重要作用。专注于他对仿生学和放射性药物主题的贡献，

更新日期：2018-05-04

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