Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334,Journal of Natural Products

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Bioactive α-Pyrone Derivatives from the Endolichenic Fungus Dothideomycetes sp. EL003334
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-04-04 00:00:00 , DOI: 10.1021/acs.jnatprod.7b01022
Gil Soo Kim _{1,

2} , Wonmin Ko ₃ , Jong Won Kim ₁ , Min-Hye Jeong ₄ , Sung-Kyun Ko _{1,

2} , Jae-Seoun Hur ₄ , Hyuncheol Oh ₃ , Jae-Hyuk Jang _{1,

2} , Jong Seog Ahn _{1,

2}

Affiliation

Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher’s method. Compound 2 inhibited nitric oxide (NO) production with IC₅₀ values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, 2 decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.

中文翻译：

内生真菌真菌Dothideomycetes sp。的生物活性α-吡喃酮衍生物。EL003334

两种新的α-吡喃酮，十二烷吡喃酮E（1）和F（2），是从内生真菌的细菌Dothideomycetes sp的培养中分离出来的。EL003334。通过光谱数据分析阐明了它们的结构。它们的绝对构型是通过改进的Mosher方法建立的。在脂多糖（LPS）诱导的BV2细胞中，化合物2抑制一氧化氮（NO）的产生，IC ₅₀值为15.0±2.8μM。化合物2降低了诱导型一氧化氮合酶（iNOS）和环氧合酶2（COX-2）的蛋白质表达水平。另外，2 降低促炎细胞因子如肿瘤坏死因子-α（TNF-α），白介素（IL）-1β和IL-6的mRNA表达水平。

更新日期：2018-04-04

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