pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets†,Nanoscale Horizons

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pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets†
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2018-04-03 00:00:00 , DOI: 10.1039/c8nh00009c
Alejandro Méndez-Ardoy _{1,

2,

3,

4,

5} , Juan R. Granja _{1,

2,

3,

4,

5} , Javier Montenegro _{1,

2,

3,

4,

5}

Affiliation

The controlled one-dimensional supramolecular polymerization of synthetic building blocks in confined spaces constitutes a key challenge to simplify the understanding of the fundamental physical principles behind the behavior of more complex encapsulated polymer networks. Cyclic peptide nanotubes constitute an optimal scaffold for the fabrication of hierarchical one-dimensional self-assembled architectures. Herein we report the pH-controlled nanotube formation and fibrillation of supramolecular cyclic peptides in confined aqueous droplets. The externally triggered self-assembly of these peptides gave rise to viscoelastic hydrogels in which the one-dimensional molecular arrangement was perfectly preserved from the nano- to the micro-scale. The cyclic peptide building blocks were confined inside water microdroplets and the base-triggered supramolecular polymerization was externally triggered and followed by confocal microscopy showing that the confined fibrillation spanned and affected the shape of the droplet micro container.

中文翻译：

pH触发的封闭在水微滴中的环状肽纳米管的自组装和水凝胶化†

密闭空间中合成构件的受控一维超分子聚合构成了一个关键挑战，即要简化对更复杂的封装聚合物网络行为背后的基本物理原理的理解。环状肽纳米管构成用于制造分层一维自组装体系结构的最佳支架。在本文中，我们报道了在受限的水性液滴中pH控制的纳米管形成和超分子环肽的原纤化。这些肽的外部触发自组装产生了粘弹性水凝胶，其中一维分子排列从纳米级到微米级都得到了完美的保留。

更新日期：2018-04-03

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