FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCF^FBW7 plays key roles in regulating cell cycle progression, differentiation, and stem cell maintenance largely through targeting a broad range of oncogenic substrates for proteasome-dependent degradation. The identification of an increasing number of FBW7 substrates for ubiquitination, and intensive in vitro and in vivo studies have revealed a network of signaling components controlled by FBW7 that contributes to metabolic regulation as well as its tumor suppressor role. Here we mainly focus on recent findings that highlight a critical role for FBW7 in cancer and metabolism.

FBW7是功能最完备的F-box蛋白之一，可作为SCF（Skp1-Cullin 1-F-box蛋白）E3泛素连接酶复合物的底物识别亚基。SCF ^FBW7在很大程度上通过靶向广泛的致癌底物来实现蛋白酶体依赖性降解，从而在调节细胞周期进程，分化和干细胞维持中起关键作用。越来越多的泛素化FBW7底物的鉴定，以及深入的体外和体内研究，揭示了由FBW7控制的信号成分网络，该网络有助于代谢调节及其肿瘤抑制作用。在这里，我们主要关注于最近的发现，这些发现突出了FBW7在癌症和新陈代谢中的关键作用。