Miuramides A and B, Trisoxazole Macrolides from a Mycale sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells,Journal of Natural Products

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Miuramides A and B, Trisoxazole Macrolides from a Mycale sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-04-03 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00101
Rei Suo ₁ , Kentaro Takada ₁ , Hisanori Kohtsuka ₂ , Yuji Ise ₃ , Shigeru Okada ₁ , Shigeki Matsunaga ₁

Affiliation

Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent cytotoxicity against 3Y1 cells.

中文翻译：

来自Mycale sp。的Miuramides A和B，三恶唑大环内酯类。海洋海绵诱导培养的哺乳动物细胞中的表型。

Mycale sp。提取物的形态学指导的基于细胞的筛选。海洋海绵导致分离出两个三恶唑大环内酯类化合物，氨基甲酸酯类A（1）和B（2），从而诱导了3Y1细胞的特征性形态变化。通过光谱数据分析，衍生化和降解的组合，阐明了包括绝对构型在内的1的结构。两种化合物均对3Y1细胞表现出有效的细胞毒性。

更新日期：2018-04-03

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