Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation†,Organic & Biomolecular Chemistry

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Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C–N bond activation†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-04-04 00:00:00 , DOI: 10.1039/c8ob00488a
Weijie Yu _{1,

2,

3,

4} , Shuwu Yang _{1,

2,

3,

4} , Fei Xiong _{1,

2,

3,

4} , Tianxiang Fan _{1,

2,

3,

4} , Yan Feng _{1,

2,

3,

4} , Yuanyuan Huang _{1,

2,

3,

4} , Junkai Fu _{5,

6,

7,

8,

9} , Tao Wang _{1,

2,

3,

4}

Affiliation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C–N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

中文翻译：

钯通过C–N键活化将苄基铵盐羰基化为酰胺和酯†

首次报道了一种有效的钯催化的季铵盐与CO的有效的羰基催化羰基化反应，可通过苄基的C–N键裂解产生芳基乙酰胺和芳基酸酯。该方案的特点是在CO的大气压下具有温和的反应条件，无需其他氧化剂即可进行的氧化还原中性工艺，以及适用于各种胺，醇和酚的广泛底物范围。

更新日期：2018-04-04

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